Explain how statins inhibit the HMG-CoA reductase enzyme to reduce cholesterol synthesis. Discuss how statins block the conversion of HMG-CoA to mevalonate, a crucial step in cholesterol biosynthesis, ultimately leading to decreased intracellular cholesterol levels, upregulation of LDL receptors, and ...
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Describe how tetracyclines inhibit bacterial protein synthesis to combat bacterial infections. Discuss how tetracyclines bind to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl-tRNA molecules to the mRNA-ribosome complex, leading to inhibition of protein synthesis and bacterial growth.