I’m fascinated by the intricate specificity of antimalarial drugs, which selectively target the malaria parasite while sparing healthy cells in the human body. Could you please shed some light on the precise molecular mechanisms or cellular pathways that enable this ...
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Provide an in-depth explanation of how penicillins interfere with bacterial cell wall synthesis. Discuss how penicillins bind to penicillin-binding proteins (PBPs), disrupting the cross-linking of peptidoglycan chains, thereby weakening the bacterial cell wall and promoting bacterial cell lysis and death.
How do drugs that inhibit HMG-CoA Reductase exert their therapeutic effect in individuals with hypercholesterolemia? Please provide a comprehensive explanation of the molecular mechanism involved.