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Explain how statins inhibit the HMG-CoA reductase enzyme to reduce cholesterol synthesis. Discuss how statins block the conversion of HMG-CoA to mevalonate, a crucial step in cholesterol biosynthesis, ultimately leading to decreased intracellular cholesterol levels, upregulation of LDL receptors, and ...
Describe how antiviral drugs, particularly antiretroviral therapy (ART), suppress viral replication in HIV-positive individuals. Discuss how ART targets various stages of the viral life cycle, such as viral entry, reverse transcription, integration, and maturation, thereby inhibiting viral replication and preserving ...
How do drugs that inhibit HMG-CoA Reductase exert their therapeutic effect in individuals with hypercholesterolemia? Please provide a comprehensive explanation of the molecular mechanism involved.








